Interactive and combined effects of body roundness index and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio on diabetes mellitus and the mediating effects of TG/HDL-C in middle-aged and elderly adults: A nationwide prospective cohort study
Authors' conclusion
BRI and TG/HDL-C ratio are advantageous predictive factors for identifying DM risk in the Chinese elderly population. TG/HDL-C ratio partially mediates the association between BRI and DM.
Study context
- Population
- Middle-aged and elderly Chinese adults without baseline diabetes mellitus (DM), China Health and Retirement Longitudinal Study (CHARLS); 44.2% men, mean age 57.4 years
- Participants
- 6,836 participants
- Exposure
- Body roundness index (BRI) and TG/HDL-C ratio as exposures for incident DM, with TG/HDL-C ratio as mediator
- Outcome
- Incidence of DM determined by guidelines diagnosis or self-report
Methodological detailsnationwide, China Health and Retirement Longitudinal Study (CHARLS) 2012 and 2015
- Nationwide
- China Health and Retirement Longitudinal Study (CHARLS) 2012 and 2015
Main finding
As reported in the abstract
Incident DM
Developed DM during follow-up
633
9.3 %
Indirect association HR for DM per one-unit increase in BRI (adjusted)
1.003
TG/HDL-C ratio mediating effect
16.9 %
Observational data: associations, not effects.
Further findings
Interaction between BRI and TG/HDL-C ratio with DM
- Additive interaction
- 6.79[0.64-12.93]
- Multiplicative interaction
- 2.19[1.04-4.61]
Prediction of incident DM by BRI and TG/HDL-C ratio
- AUC
- 0.645
Original publication
Interactive and combined effects of body roundness index and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio on diabetes mellitus and the mediating effects of TG/HDL-C in middle-aged and elderly adults: A nationwide prospective cohort study. Diabetes Res Clin Pract. Published 28 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →