Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study
Authors' conclusion
High circulating DBP concentrations are associated with better mobility and reduced mortality after hip fracture surgery. The role of DBP as an acute phase reactant to tissue injury and clinical outcomes should be addressed in future study.
Study context
- Population
- Patients with hip fracture undergoing repair surgery; mean age 81 ± 9 years, BMI 25 ± 4 kg/m², 72% female
- Participants
- 260 patients
- Comparison
- Highest vs lowest D binding protein (DBP) tertile
- Primary endpoint
- Mobility and mortality by DBP tertiles
- Follow-up
- Mobility at 30 and 60 days; mortality at 60 days after surgery
Methodological detailsmultisite, North American
- Multisite
- North American
Primary result
As reported in the abstract
Highest DBP tertile vs Lowest DBP tertileOdds ratio (95% CI)P value
Greater mobility at 30 days
2.66(1.43–4.92)
P = 0.002Greater mobility at 60 days
2.31(1.17–4.54)
P = 0.014Reduced mortality at 60 days
0.18(0.04–0.86)
P = 0.032Secondary outcomes
Total 25(OH)D by DBP tertile
- Total 25(OH)D did not differ between tertiles
- 22.0 ± 9.5 ng/mL
Tissue injury markers, patients vs controls · before and 2 to 4 days after surgery
- DBP and gelsolin lower, IL-6, CRP and F-actin higher in patients vs controls
- P < 0.01
- Markers worsened after surgery
- P < 0.01
- Measured in 100 randomly selected patients and controls
Original publication
Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study. J Clin Endocrinol Metab. Published 26 August 2023. doi:10.
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