Circulating neurodegenerative brain injury markers and hip fracture and fall hospitalizations: the Cardiovascular Health Study
Authors' conclusion
Neurofilament light chain was independently associated with an incident risk of hip fracture and fall hospitalizations.
Study context
- Population
- Cardiovascular Health Study participants; mean age 77.9 yr; 60% women
- Participants
- 2,141 participants
- Exposure
- Higher vs lower circulating brain injury markers
- Outcome
- Incident hip fracture and fall hospitalizations
- Follow-up
- Median 11 yr
Methodological detailsmultivariable-adjusted Cox models, HR per doubling (log2 transformed) of marker
- Multivariable-adjusted Cox models
- HR per doubling (log2 transformed) of marker
Main finding
As reported in the abstract
Incident hip fracture (304 events) per doubling of marker
Glial fibrillary acidic protein (GFAP) doubling: higher risk of hip fracture
22%
p = .048
NfL doubling: higher risk of hip fracture
42%
p < .001
Observational data: associations, not effects.
Further findings
Incident fall hospitalizations (284 events) per doubling of marker · median follow-up 11 yr
- NfL: increased risk of hospitalization for falls
- 47%
- Total Tau, UCH-L1 and GFAP: no association with fall hospitalizations
Original publication
Circulating neurodegenerative brain injury markers and hip fracture and fall hospitalizations: the Cardiovascular Health Study. J Bone Miner Res. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →