Autophagy markers are decreased in bone of osteoporotic patients: a monocentric comparative study
Authors' conclusion
These results demonstrate for the first time that postmenopausal OP patients have a deficit in bone autophagy level and suggest that HUNK could be the factor linking estrogen loss and autophagy decline.
Study context
- Population
- Postmenopausal women hospitalized for femoral neck fracture or total hip replacement, very strict exclusion criteria
- Comparison
- Postmenopausal women with osteoporotic femoral neck fracture vs total hip replacement controls
- Outcome
- Bone autophagy markers (Western blot)
Methodological detailsmonocentric, Western blot used to analyze autophagy level
- Monocentric
- Western blot used to analyze autophagy level
Main finding
As reported in the abstract
- Autophagosome marker LC3-II protein expression significantly decreased in bone of osteoporosis (OP) vs Control
- HUNK protein expression significantly reduced in bone of OP
Original publication
Autophagy markers are decreased in bone of osteoporotic patients: a monocentric comparative study. Eur J Endocrinol. Published 2 March 2024. doi:10.
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