Association of Serum Phosphate, Calcium and Alkaline Phosphatase With Risk of Incident Fractures in Healthy Older Adults
Primary result · Incident fractureResult — go to the resultHazard ratio 1.78 95% CI 1.25–2.54Authors' conclusion
This result confirms that high-normal serum phosphate levels are associated with increased fracture risk in older men.
Study context
- Population
- Initially healthy older Australian participants of the ASPREE-Fracture substudy with serum calcium (Ca), phosphate and alkaline phosphatase (ALP) measurement907 incident fractures
- Participants
- 9,915 participants
- Comparison
- Top decile vs deciles 4–7 of serum phosphate, Ca and ALP
- Primary endpoint
- Incident fracture
- Follow-up
- 3.9 (SD 1.4) years
Methodological detailsASPREE-Fracture substudy, Cox regression, deciles with D4–D7 as reference, restricted cubic splines
- ASPREE-Fracture substudy
- Cox regression
- Deciles with D4–D7 as reference
- Restricted cubic splines
Primary result
As reported in the abstract
Hazard ratio
1.78
95% CI 1.25–2.54
D10vs Deciles 4 to 7
HR 1.78 (95% CI 1.25–2.54)
- No such association observed for women
- HR 1.09; 95% CI, 0.83-1.44
Further findings
Population attributable fraction, men in D10 phosphate
- Population attributable fraction
- 6.9%
Original publication
Association of Serum Phosphate, Calcium and Alkaline Phosphatase With Risk of Incident Fractures in Healthy Older Adults. J Clin Endocrinol Metab. Published 1 March 2024. doi:10.
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