More Rapid Bone Mineral Density Loss in Older Men With Diabetes: The Osteoporotic Fractures in Men (MrOS) Study
Authors' conclusion
Men with type 2 diabetes, but not prediabetes, experienced accelerated bone loss compared to participants with normoglycemia. More rapid bone loss predicts increased risk of fractures and mortality in broader populations.
Study context
- Population
- Men aged ≥ 65 years in the MrOS study; diabetes status by self-report, diabetes medication use, or elevated fasting serum glucose at baseline5,994 enrolled
- Participants
- 4,095 men
- Exposure
- T2D or prediabetes vs normoglycemia
- Outcome
- Change in hip BMD by DXA
- Follow-up
- After 4.6 ± 0.4 years
Methodological detailsmultisite, adjusted generalized linear models
- Multisite
- Adjusted generalized linear models
Main finding
As reported in the abstract
Hip BMD change · 4.6 ± 0.4 years
T2D
- 2.23
CI −2.54–-1.91 · %
Prediabetes
−1.45
CI −1.63–-1.26 · %
Normoglycemia (NG)
−1.57
CI −1.73–-1.41 · %
T2D vs NG: P < 0.001 · Prediabetes vs NG: P = 0.33
Observational data: associations, not effects.
Further findings
Diabetes medication use and hip bone mineral density (BMD) loss among men with T2D
- Thiazolidinedione (TZD), insulin, and SU use were associated with greater hip BMD loss
Original publication
More Rapid Bone Mineral Density Loss in Older Men With Diabetes: The Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab. Published 26 February 2024. doi:10.
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