3D Finite Element Models Reconstructed From 2D Dual‐Energy X‐Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in Osteoporotic Fractures in Men (MrOS) Sweden Cohort
Authors' conclusion
This is the first time that FE models outperformed aBMD in predicting incident hip fractures in a population-based prospectively followed cohort based on 3D FE models obtained from a 2D DXA scan.
Study context
- Population
- Men in the MrOS Sweden cohort: hip fracture cases (<10 years from baseline) with 2 controls each matched by age, height and BMI; and men who had fallen the year before their hip DXA scan120 cases + 2 controls each
- Comparison
- DXA-based 3D finite element (FE)-predicted proximal femoral strength vs areal bone mineral density (aBMD) for predicting incident hip fracture
- Outcome
- Prediction of incident hip fractures (AUROC)
Methodological detailsnested case-control and fallers subcohorts, population-based prospective cohort
- Nested case-control and fallers subcohorts
- Population-based prospective cohort
Performance
As reported in the abstract
Incident hip fracture prediction (AUROC)
ΔAUROC
0.06
hip fracture cases and controls cohort; better prediction with FE
ΔAUROC
0.22
fallers cohort (15 of 86 sustained hip fracture within 10 years); better prediction with FE
Original publication
3D Finite Element Models Reconstructed From 2D Dual‐Energy X‐Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in Osteoporotic Fractures in Men (MrOS) Sweden Cohort. J Bone Miner Res. Published 7 August 2023. doi:10.
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