Association Between Sarcopenia and Fracture Risk in a Population From the UK Biobank Database
Authors' conclusion
In a middle-aged population, the fracture and MOF risks were higher in both presarcopenic and sarcopenic participants compared with nonsarcopenic participants.
Study context
- Population
- UK Biobank participants; women 54.4%; median age 58.0 years (IQR 51.0–63.0)
- Participants
- 387,025 participants
- Exposure
- Presarcopenia and sarcopenia vs nonsarcopenia
- Presarcopenia subgroup 1n = 18,257
- Presarcopenia subgroup 2n = 7,940
- Sarcopenian = 1,124
- Outcome
- Incident fracture (location compatible with osteoporotic origin)
- Follow-up
- Median 12.0 years (IQR 11.4-12.6 years)
Methodological detailsUK Biobank cohort, EWGSOP2 criteria, Cox proportional hazards models, adjusted for sarcopenia and osteoporosis risk factors
- UK Biobank cohort
- EWGSOP2 criteria
- Cox proportional hazards models, adjusted for sarcopenia and osteoporosis risk factors
Main finding
As reported in the abstract
Incident fracture (osteoporotic-compatible location) · median follow-up 12.0 years
Adjusted hazard ratio (CI)
Presarcopenic subgroup 1low HGS only
1.26(1.19–1.33)
Presarcopenic subgroup 2low SMI only
1.20(1.11–1.30)
Sarcopeniclow HGS and low SMI
1.30(1.08–1.56)
Observational data: associations, not effects.
Further findings
Major osteoporotic fracture (MOF) · median follow-up 12.0 years
| aHR (CI) | ||
|---|---|---|
| Presarcopenic subgroup 1Low HGS only | 1.30 (1.21–1.40) | |
| Presarcopenic subgroup 2Low SMI only | 1.19 (1.08–1.72) | |
| SarcopenicLow HGS and low SMI | 1.18 (0.93–1.49) | |
| 0.512Adjusted hazard ratio (log scale) |
- Major osteoporotic fracture (MOF): Cox models adjusted for sarcopenia and osteoporosis risk factors
Original publication
Association Between Sarcopenia and Fracture Risk in a Population From the UK Biobank Database. J Bone Miner Res. Published 3 August 2023. doi:10.
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