Sarcopenia definitions and their association with fracture risk in older Swedish women
Authors' conclusion
In conclusion, sarcopenia defined by SDOC, incorporating muscle function/strength, was the only sarcopenia definition associated with fracture risk in older women.
Study context
- Population
- Older Swedish women, mean age 77.8 years
- Participants
- 2,883 women
- Exposure
- Sarcopenia vs no sarcopenia
- Sarcopenia Definitions and Outcomes Consortium (SDOC) sarcopenian = 129
- European Working Group on Sarcopenia in Older People (EWGSOP2) sarcopenian = 360
- Asian Working Group for Sarcopenia (AWGS) sarcopenian = 296
- Outcome
- Prevalence of three sarcopenia definitions and their associations with fracture risk (all fractures, MOF, hip fractures), adjusted for FRAX-based risk factors
- Follow-up
- 6.4 ± 1.3 (mean ± SD) yr
Main finding
As reported in the abstract
SDOC sarcopenia vs No sarcopeniaHazard ratio (95% CI)
Any fractures; adjusted for FRAX clinical risk factors
1.48(1.10–1.99)
MOF; adjusted for FRAX clinical risk factors
1.42(1.03–1.98)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MortalitySDOC sarcopeniavs No sarcopeniaAdjusted for age and FRAX variables | 3.41 (2.51–4.62) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Sarcopenia definitions and their association with fracture risk in older Swedish women. J Bone Miner Res. Published 9 February 2024. doi:10.
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