Radiofrequency Echographic Multi Spectrometry (REMS) for the evaluation of bone health in systemic lupus erythematosus (SLE)
Authors' conclusion
REMS and DXA showed a fair to moderate agreement in osteoporosis diagnosis and in fracture discrimination in SLE patients.
Study context
- Population
- SLE patients, including GC-treated44 GC-treated
- Participants
- 106 patients
- Comparison
- REMS vs DXA for bone mineral density (BMD) assessment
- Outcome
- Diagnostic agreement between REMS and DXA for BMD
Performance
As reported in the abstract
Agreement in osteoporosis classification (Cohen's kappa)
| Test or model | Sensitivity for osteoporosis | Specificity for osteoporosis |
|---|---|---|
| REMS | 45% | 88.4% |
REMS
Sensitivity for osteoporosis45%
Specificity for osteoporosis88.4%
- Agreement slight to moderate; κ at lumbar spine (LS), all patients
- 0.229
- κ at femoral neck (FN), GC-treated patients
- 0.549
- BMD significantly lower with REMS vs DXA across all skeletal sites
- P < 0.001
Further findings
Fracture discrimination
- Both REMS and DXA identified significant BMD differences between patients with and without vertebral fractures across all sites
- ROC analysis: similar discriminative ability for fracture risk between REMS and DXA
Association with demographics
- REMS BMD more strongly associated with age, sex and BMI
Original publication
Radiofrequency Echographic Multi Spectrometry (REMS) for the evaluation of bone health in systemic lupus erythematosus (SLE). Osteoporos Int. Published 25 December 2025. doi:10.
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