Bone mineral density in childhood cancer survivors during and after oncological treatment: A systematic review and meta-analysis
Authors' conclusion
In conclusion, childhood cancer patients and survivors experience reductions in BMD.
Study context
- Population
- Children and adolescents diagnosed with cancer before age 18, undergoing cancer treatment or having completed treatments, with DXA lumbar spine, hip/femoral neck or total body bone mineral density (BMD) Z-scores
- Participants
- 4,547 children49 studies
- Outcome
- BMD Z-scores
Methodological details3-level mixed-effects meta-analysis, meta-regression, Searched CINAHL, Embase, PubMed, SPORTDiscus and Web of Science from inception to November 2023
- 3-level mixed-effects meta-analysis
- Meta-regression
- Searched CINAHL, Embase, PubMed, SPORTDiscus and Web of Science from inception to November 2023
Pooled result
As reported in the abstract
- Children undergoing cancer treatment: change from baseline across sites, MD (95% CI −0.62 to −0.11; p = .01)
- - 0.36
- Child and adolescent childhood cancer survivors (CCS) after treatment: lumbar spine (95% CI −1.17 to −0.54; p < .001)
- - 0.85 SD
- Child and adolescent CCS after treatment: hip/femoral neck (95% CI −1.38 to −0.68; p < .001)
- - 1.03 SD
- Adult CCS: lumbar spine (95% CI −0.67 to −0.26; p < .001)
- - 0.46 SD
- Adult CCS: hip/femoral neck (95% CI −0.57 to −0.16; p < .001)
- - 0.36 SD
Further pooled results
Moderators of hip/femoral neck BMD Z-scores (meta-regression)
- Age at assessment
- P = 0.006
- Time from diagnosis
- P = 0.004
- Sex
- P = 0.037
- Height
- P = 0.026
Moderators of lumbar spine BMD Z-scores (meta-regression)
- Age at assessment
- P = 0.018
- Sex
- P = 0.015
Original publication
Bone mineral density in childhood cancer survivors during and after oncological treatment: A systematic review and meta-analysis. Osteoporos Int. Published 27 March 2025. doi:10.
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