Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis
Authors' conclusion
Low BMD could be a novel risk factor and early predictor for cirrhosis, with consistent associations observed in multiple sensitivity analyses.
Study context
- Population
- Participants of the Hong Kong Osteoporosis Study (HKOS) with bone mineral density (BMD) measured by DXA at lumbar spine, femoral neck, total hip and trochanter
- Participants
- 7,752 participants
- Exposure
- Higher vs lower BMD T-scores
- Outcome
- Incident cirrhosis
- Follow-up
- Median 18.43 years
Methodological detailslinked to territory-wide electronic health records, Cox proportional hazard models
- Linked to territory-wide electronic health records
- Cox proportional hazard models
Main finding
As reported in the abstract
Incident cirrhosis per higher BMD T-score
Incident cirrhosis cases
42
Femoral neck T-score: HR
0.56
95% CI 0.39–0.82
Total hip T-score: HR
0.60
95% CI 0.44–0.82
Trochanter T-score: HR
0.63
95% CI 0.46–0.88
Observational data: associations, not effects.
Further findings
Participants without baseline cirrhosis risk factors; further adjustment for baseline alkaline phosphatase, albumin and alanine transaminase
- Similar associations observed
Sensitivity analyses
- Consistent relationships in multiple sensitivity analyses
Original publication
Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis. J Clin Endocrinol Metab. Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →