Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index
Authors' conclusion
Elevated PTH is independently associated with greater large artery stiffness in PHPT, and this effect appears to be at least partially reversible following PTX. However, changes in PTH were not associated with short-term changes in renal microvascular resistance, suggesting a delayed or less reversible effect on renal vasculature.
Study context
- Population
- Primary hyperparathyroidism (PHPT) patients undergoing elective PTX; 80% women, median age 64 years
- Participants
- 107 patients
- Exposure
- Before vs 6 months after PTX
- Outcome
- Associations between PTH and vascular parameters (PWV, AI, PP, RRI) before and after PTX
- Follow-up
- Baseline and 6 months postoperatively
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Higher parathyroid hormone (PTH) independently associated with increased pulse wave velocity (PWV) (adjusted β, 95% CI 0.02-0.18)
.10
Baseline PTH positively associated with Renal Resistive Index (RRI) (β, 95% CI 0.19-4.13); not persisting after PTX
2.16
Observational data: associations, not effects.
Original publication
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