Osteoporosis, bone & mineral

A programmatic approach to osteoporosis treatment: insight from a 20-year longitudinal study

Osteoporos IntPublished Retrospective cohort study

Authors' conclusion

Over two decades, our osteoporosis team reported significantly higher treatment rates than national averages. Overall treatment rates were similar between patients seen in osteoporosis and specialty clinic; however, the osteoporosis clinic reported higher rates than the specialty or PCP clinic in time-stratified analysis and PCP clinic overall.

Study context

Population
Patients with osteoporosis, 2002–2022 (median age 76)
Participants
44,135 patient records
Exposure
Osteoporosis clinic vs specialty clinic vs PCP clinics
Outcome
Osteoporosis treatment rates in patients seen in a structured osteoporosis clinic, compared with the national benchmark
Methodological detailslongitudinal, seven 3-year time periods, chi-square, Fisher's exact tests or logistic regression with generalized estimating equations (GEE)
  • Longitudinal
  • Seven 3-year time periods
  • Chi-square, Fisher's exact tests or logistic regression with GEE

Main finding

As reported in the abstract

Treatment rate, 3-year

Osteoporosis clinic vs Specialty clinic: P = 0.124 · Osteoporosis clinic vs PCP: P < 0.0001

Observational data: associations, not effects.

Further findings

Treatment rate, 5-year — Osteoporosis clinic vs Specialty clinic

P = 0.856

OutcomeP value
Treatment rate, 5-yearOsteoporosis clinic vs PCPP < 0.0001

Treatment rate trend over time (all patients)

3-year treatment rate declined 73.9% to 56.5%
P = 0.003
5-year treatment rate declined 72.7% to 47.4%
P < 0.0001

Treatment rates by insurance type, race and gender

Similar by insurance type and race
Women had higher overall treatment rates than men

Original publication

A programmatic approach to osteoporosis treatment: insight from a 20-year longitudinal study. Osteoporos Int. Published 22 December 2025. doi:10.1007/s00198-025-07811-8

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