Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism
Authors' conclusion
Clinical and subclinical CAD was observed in 3.2% and 12.8% of cHypoPT patients. The increased prevalence of CAD, CAC and aortic-valve calcification in cHypoPT above 50 years of age suggested their careful cardiac evaluation during follow-up.
Study context
- Population
- Patients with chronic nonsurgical hypoparathyroidism (M:F = 50:44; age 45 ± 15 years; illness 18.6 ± 9.3 years)
- Participants
- 94 / 101 / 148
- Exposure
- Nonsurgical chronic hypoparathyroidism (cHypoPT) vs age-matched healthy controls (Group A) and cardiology-clinic referrals (Group B)
- cHypoPTn = 94
- Group An = 101reference
- Group Bn = 148reference
- Outcome
- Prevalence of CAC and CAD in cHypoPT
Methodological detailsThose with dyspnoea, angina, syncope, abnormal ECG, echocardiography or significant coronary artery calcification (CAC) underwent coronary angiography or myocardial-perfusion-stress imaging
- Those with dyspnoea, angina, syncope, abnormal ECG, echocardiography or significant CAC underwent coronary angiography or myocardial-perfusion-stress imaging
Main finding
As reported in the abstract
- Known coronary artery disease (CAD)
- 1 of 94
- Required evaluation for CAD on screening
- 17
- Severe coronary stenosis among those evaluated
- 2 of 17
- Subclinical CAD among those evaluated
- 12
- CAC
- 21.5%
- Aortic-valve calcification
- 11.8%
Observational data: associations, not effects.
Further findings
| Outcome | cHypoPT | Group A | P value |
|---|---|---|---|
| Elevated hsCRPcHypoPT vs Group A · higher in cHypoPT | 52% | 32% | P < 0.01 |
Clinical and subclinical CAD, CAC and aortic-valve calcification in cHypoPT ≥50 years
- Clinical CAD
- 8.1%
- Subclinical CAD
- 27.0%
- CAC
- 52.8%
- Aortic-valve calcification
- 27.8%
Factors associated with CAD in cHypoPT
- CAC and hypertension associated with CAD
- CAD and CAC not associated with long-term calcemic or phosphatemic control or intracranial calcification
Original publication
Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism. Clin Endocrinol (Oxf). Published 1 January 2023. doi:10.
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