Significance of QTc Interval in Chronic Hypoparathyroidism and its Correlates
Authors' conclusion
One-fifth of patients with cHypoPT had arrhythmic symptoms and a significant proportion had prolonged QTc. This highlights the need for close monitoring of patients with cHypoPT for arrhythmic symptoms and QTc prolongation. The serum total calcium should be maintained to at least 8.3 mg/dL to minimize the risk of potentially life-threatening arrhythmia in cHypoPT.
Study context
- Population
- Nonsurgical patients with chronic hypoparathyroidism (cHypoPT), tertiary care center; mean age 44.1 ± 15.4 years, 45 males
- Participants
- 88 patients
- Outcome
- QTc interval and its correlates (arrhythmic symptoms, serum total calcium, phosphate, 25(OH)D, intact PTH)
Methodological detailssingle-centre, tertiary care center
- Single-centre
- Tertiary care center
Main finding
As reported in the abstract
QTc interval
cHypoPT cohort
428
mean · ± 34 · ms
- Prolonged QTc
- 13.6%
- Correlation between QTc and same-day serum total calcium (inverse)
- r = −0.43, P < .001
- Mean serum total calcium, prolonged QTc vs others (mg/dL)
- 7.05 ± 1.94 vs 8.49 ± 1.01, P = .02
- Increase in QTc per mg/dL decrease in serum total calcium
- 13 ms
Observational data: associations, not effects.
Further findings
Arrhythmic symptoms (palpitation/giddiness/syncope)
- Patients with arrhythmic symptoms
- 21.6%
- Significantly higher mean QTc in patients with arrhythmic symptoms
- P = 0.02
- Tended to have lower mean serum total calcium during follow-up
- P = 0.06
Serum total calcium discriminating prolonged QTc (ROC)
- Cut-off
- 8.3 mg/dL
- AUC
- 0.72 (0.51, 0.93) (95% CI)
Original publication
Significance of QTc Interval in Chronic Hypoparathyroidism and its Correlates. J Clin Endocrinol Metab. Published 17 May 2024. doi:10.
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