Nonsurgical hypoparathyroidism is associated with skeletal muscle dysfunction and restrictive lung disease
Authors' conclusion
Detailed testing of patients with HP without overt muscle and lung diseases revealed significant impairment in parameters of skeletal muscle function. Myopathy and RLD were observed in a considerable proportion of patients with HP.
Study context
- Population
- Patients with nonsurgical hypoparathyroidism without overt muscle and lung diseases (mean age 37.7 years, 60% males) and matched healthy controls
- Participants
- 30 vs 40
- Comparison
- Nonsurgical hypoparathyroidism (HP) vs healthy controls
- HPn = 30
- Controlsn = 40reference
- Outcome
- Skeletal muscle and pulmonary function
Methodological detailsobservational, age-, sex- and body mass index (BMI)-matched controls
- Observational
- Age-, sex- and BMI-matched controls
Main finding
As reported in the abstract
- HP vs Controls: P = 0.01
- HP vs Controls: P < 0.001
- HP vs Controls: P = 0.08
- HP vs Controls: P = 0.01
- HP vs Controls: P = 0.01
- HP vs Controls: P = 0.05
Observational data: associations, not effects.
Further findings
Serum calcium · lower with HP
P < 0.001
Serum magnesium · lower with HP
P = 0.04
Original publication
Nonsurgical hypoparathyroidism is associated with skeletal muscle dysfunction and restrictive lung disease. Eur J Endocrinol. Published 21 July 2023. doi:10.
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