The Clinical and Skeletal Effects of Long-Term Therapy of Hypoparathyroidism With rhPTH(1-84)
Authors' conclusion
These results demonstrate sustained biochemical stability but overall decreases in bone mass.
Study context
- Population
- Hypoparathyroidism (HypoPT) patients (16 postsurgical, 11 nonsurgical) treated with rhPTH(1–84)14 followed 12 years
- Participants
- 27 patients
- Outcome
- Tibia cortical volumetric BMD (vBMD) change from baseline (HRpQCT)
- Follow-up
- Years 5, 8 and 12
Main finding
As reported in the abstract
- Year 5
- −20.0% ± 1.5%
- Year 8
- −8.5% ± 1.6%
- Year 12
- −10.3% ± 2.2%
- All significantly below mean baseline
- p < 0.001
Observational data: associations, not effects.
Further findings
Tibia cortical porosity change from baseline (high-resolution-peripheral quantitative computed tomography (HRpQCT)) · years 5, 8 and 12
- Year 5
- 17.4% ± 10% (p < 0.05)
- Year 8
- 55.2% ± 11% (p < 0.001)
- Year 12
- 83.5% ± 14% (p < 0.001)
- Similar pattern of increase at the radius
Supplements, estimated glomerular filtration rate (eGFR) and serum calcium
- Reductions in need for supplemental calcium and active vitamin D maintained
- eGFR did not decline
- Serum calcium maintained within lower limit of normal range
Areal bone mineral density (aBMD) by DXA
- Increase at lumbar spine; decrease at distal 1/3 radius
Failure load · year 12
- Higher than normal at baseline, decreased but remained above normal at year 12
Original publication
The Clinical and Skeletal Effects of Long-Term Therapy of Hypoparathyroidism With rhPTH(1-84). J Bone Miner Res. Published 1 February 2023. doi:10.
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