Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR)
Authors' conclusion
Overall, 35% of postmenopausal women had osteoporosis by BMD or prior fragility fracture, and 4% had both. Three men ≥ 50 years had osteoporosis by BMD or fragility fracture (33.3%; n = 3/9). This study suggests that close follow-up of skeletal health is necessary in postmenopausal women with chronic HypoPT and men ≥ 50 years.
Study context
- Population
- Adults with chronic hypoparathyroidism (HypoPT) from the Canadian National Hypoparathyroidism Registry; mean (SD) age at onset 40.7 (16.8) years, disease duration 11.2 (8.6) years; 74.3% postsurgicalanalysed
- Participants
- 101 adults
- Exposure
- Men vs Premenopausal vs Postmenopausal
- Menn = 18
- Premenopausaln = 35
- Postmenopausaln = 48
- Outcome
- Osteoporosis by BMD or fragility fracture
- Follow-up
- Baseline
Methodological detailsnational registry, baseline data
- National registry
- Baseline data
Main finding
As reported in the abstract
Postmenopausal
35%
- Postmenopausal women with both osteoporosis by bone mineral density (BMD) and prior fragility fracture
- 4%
- Men ≥ 50 with osteoporosis by BMD or fragility fracture
- 33.3%; n = 3/9
Observational data: associations, not effects.
Further findings
BMD at lumbar spine (LS), femoral neck (FN), total hip (TH) and trabecular bone score (TBS) · baseline
- Significantly lower in postmenopausal vs premenopausal women
Treatment at baseline
- Calcium supplements
- 89%
- Active vitamin D
- 80%
Original publication
Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR). Osteoporos Int. Published 16 February 2025. doi:10.
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