Bone Marrow Adipose Tissue Is Increased in Postmenopausal Women With Postsurgical Hypoparathyroidism
Authors' conclusion
We demonstrate for the first time that BMAT is increased in postmenopausal women with postsurgical hypoparathyroidism and negatively associated with trabecular microarchitecture.
Study context
- Population
- Postmenopausal women with chronic postsurgical hypoparathyroidism and healthy postmenopausal women, ambulatory referral center
- Participants
- 29 vs 31
- Exposure
- Postmenopausal women with postsurgical hypoparathyroidism (HypoPT) vs healthy postmenopausal controls
- HypoPTn = 29
- Controlsn = 31reference
- Outcome
- Bone marrow adipose tissue (BMAT) by magnetic resonance imaging (MRI) and 1H-MRS (PRESS sequences on L3 body)
Methodological detailspilot study, single ambulatory referral center
- Pilot study
- Single ambulatory referral center
Main finding
As reported in the abstract
BMAT (L3, 1H-MRS)
- HypoPT vs Controls: P < 0.0001
- HypoPT vs Controls: P < 0.001
- HypoPT vs Controls: P < 0.0001
Observational data: associations, not effects.
Further findings
Correlates of fat content in HypoPT
- Fat content (FC) correlated with years since menopause and body weight in HypoPT
- P < 0.05
Trabecular bone score (TBS) vs bone marrow adipose tissue (BMAT) parameters
- TBS negatively correlated with FC and SL%
- P < 0.05
- TBS positively correlated with residual lipids and water content
- P < 0.05
Original publication
Bone Marrow Adipose Tissue Is Increased in Postmenopausal Women With Postsurgical Hypoparathyroidism. J Clin Endocrinol Metab. Published 28 February 2023. doi:10.
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