Risk of developing age-related macular degeneration in patients with osteoporosis: a population-based, longitudinal follow-up study
Main finding · Newly diagnosed AMDResult — go to the resultHazard ratio 1.34 95% CI 1.22–1.47Authors' conclusion
This longitudinal follow-up study revealed an increased risk of developing AMD in both men and women with osteoporosis.
Study context
- Population
- Individuals aged 50 to 79, Longitudinal Health Insurance Database 2005 (Taiwan's National Health Insurance research database)1:1 propensity score-matched
- Exposure
- Osteoporosis vs propensity score-matched individuals without osteoporosis
- Osteoporosisn = 23,611
- Outcome
- Occurrence of newly diagnosed AMD
Methodological detailspopulation-based, longitudinal follow-up, propensity score-matched (age, sex, comorbidities, socioeconomic status), Cox proportional hazard regression
- Population-based
- Longitudinal follow-up
- Propensity score-matched (age, sex, comorbidities, socioeconomic status)
- Cox proportional hazard regression
Main finding
Newly diagnosed AMD
Hazard ratio
1.34
95% CI 1.22–1.47
P < 0.05
Osteoporosisvs Comparison
HR 1.34 (95% CI 1.22–1.47); P < 0.05
As reported in the abstract
- AMD-free survival rate significantly lower in the osteoporosis group than the comparison group
- P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| AMD risk in men (sex-stratified analysis)Osteoporotic menvs Non-osteoporotic counterparts | 1.45 (1.20–1.76) | P = 0.0002 | |
| AMD risk in women (sex-stratified analysis)Osteoporotic womenvs Non-osteoporotic counterparts | 1.31 (1.17–1.46) | P < 0.0001 | |
| 0.512Hazard ratio (log scale) |
AMD-free survival
- AMD-free survival significantly lower in the osteoporosis group than in the comparison group
- P < 0.0001
Original publication
Risk of developing age-related macular degeneration in patients with osteoporosis: a population-based, longitudinal follow-up study. Osteoporos Int. Published 24 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →