Demographics and medical burden of osteogenesis imperfecta: a nationwide database analysis
Authors' conclusion
This study provides comprehensive real-world evidence on the clinical characteristics and high medical resource utilization of OI patients in a low prevalence region like Taiwan. Early diagnosis is crucial for improving care quality and enhancing health outcomes.
Study context
- Population
- Validated osteogenesis imperfecta (OI) patients, Catastrophic Illness Registry, National Health Insurance Research Database, Taiwan, 2008–2019M/F = 153/166
- Participants
- 319 participants
- Outcome
- Epidemiology and medical resource utilization of OI
- Follow-up
- 2008 to 2019
Methodological detailsnationwide database analysis, multivariate Cox model
- Nationwide database analysis
- Multivariate Cox model
Main finding
As reported in the abstract
- Validated before age 20
- 58%
- Prevalence
- 0.8-1.3/100,000
- Incidence
- 0.02-0.09/100,000
- Admission history (mainly pediatric and orthopedic wards)
- 69.6%
- Median admission number
- 3
- Median LOS
- 12 days
- Median inpatient cost
- ≈3,163 USD
- Received bisphosphonate treatment
- 57%
Observational data: associations, not effects.
Further findings
Mortality
- Median age of validation significantly higher in non-survival vs survival group
- 33 vs. 14 years
- Leading causes of mortality: OI-related deaths, neurovascular disease and CVD
Inpatient fracture surgeries by age at validation
- Patients validated during childhood required more inpatient fracture surgeries than those validated during adulthood
Original publication
Demographics and medical burden of osteogenesis imperfecta: a nationwide database analysis. Osteoporos Int. Published 2 April 2024. doi:10.
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