The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies
Pooled result · FractureResult — go to the resultOdds ratio 1.04 95% CI 0.93–1.16Authors' conclusion
The presence of VMS is associated with low BMD in postmenopausal women, although it does not seem to increase fracture risk.
Study context
- Population
- Peri- and postmenopausal women; PubMed, Scopus and Cochrane searched until 31 August 202312 studies in meta-analysis
- Participants
- 49,659 participants
- Comparison
- Women with vasomotor symptoms (VMS) vs women without VMS
- Outcome
- Fracture, low BMD (osteoporosis/osteopenia) and mean change in lumbar spine (LS) and femoral neck (FN) BMD
Methodological detailsResults independent of VMS severity, age and study design
- Results independent of VMS severity, age and study design
Pooled result
Fracture
Odds ratio
1.04
95% CI 0.93–1.16
VMSvs No VMS
OR 1.04 (95% CI 0.93–1.16)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Low BMD (osteoporosis/osteopenia)n=5 studies; I2 0% | 1.54 (1.42–1.67) | |
| 0.512Odds ratio (log scale) |
| Outcome | MD (g/cm²) (95% CI) | |
|---|---|---|
| LS BMDI2 85.2% | −0.019 (−0.03 to −0.008) | |
| FN BMDI2 78.2% | −0.010 (−0.021 to 0.001) | |
| −0.04−0.0200.02Difference, g/cm² (linear scale) |
Bone mineral density (BMD) association in studies excluding menopausal hormone therapy use
- Association with BMD remained significant
Original publication
The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies. Osteoporos Int. Published 2 April 2024. doi:10.
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