Morbidity Associated With Primary Hyperparathyroidism—A Population-based Study With a Subanalysis on Vitamin D
Main finding · DeathResult — go to the resultAdjusted hazard ratio 2.05 95% CI 1.97–2.13Authors' conclusion
In a large population-based study, PHPT was associated with death, diabetes, renal stones, and osteoporosis, independent of serum vitamin D concentration.
Study context
- Population
- People with primary hyperparathyroidism (PHPT) across Tayside, Scotland, 1997–2019 (66.8% female)matched cohort
- Exposure
- PHPT vs age- and gender-matched cohort
- PHPTn = 11,616
- Outcome
- Death (mortality)
- Follow-up
- Mean 8.8 years
Methodological detailsdata linkage, age- and gender-matched comparison cohort, Cox proportional hazards models
- Data linkage
- Age- and gender-matched comparison cohort
- Cox proportional hazards models
Main finding
Death
Adjusted hazard ratio
2.05
95% CI 1.97–2.13
PHPTvs Matched
adjusted HR 2.05 (95% CI 1.97–2.13)
As reported in the abstract
Observational data: associations, not effects.
Further findings
CVD
- Increased risk of CVD, HR
- 1.34 (1.24-1.45) (95% CI)
Cerebrovascular disease
- Increased risk of cerebrovascular disease, HR
- 1.29 (1.15-1.45) (95% CI)
Diabetes
- Increased risk of diabetes, HR
- 1.39 (1.26-1.54) (95% CI)
Renal stones
- Increased risk of renal stones, HR
- 3.02 (2.19-4.17) (95% CI)
Osteoporosis
- Increased risk of osteoporosis, HR
- 1.31 (1.16-1.49) (95% CI)
Outcomes after adjustment for serum vitamin D concentrations
- Participants with serum vitamin D concentrations
- 2748
- Increased risks for death, diabetes, renal stones and osteoporosis persisted, but not for CVD or cerebrovascular disease
Original publication
Morbidity Associated With Primary Hyperparathyroidism—A Population-based Study With a Subanalysis on Vitamin D. J Clin Endocrinol Metab. Published 22 February 2023. doi:10.
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