Cardiovascular Morbidity in Patients Undergoing Successful Surgery for Primary Hyperparathyroidism
Authors' conclusion
The incidence rates for mitral valve stenosis and heart failure were increased preoperatively in patients with pHPT, normalizing after surgery. In contrast, the incidence of TIA and AA remained elevated postoperatively.
Study context
- Population
- Patients with primary hyperparathyroidism who underwent PTX, identified from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery; linked with National Patient and Death Registries
- Participants
- 5,009 vs 14,983
- Exposure
- Patients with pHPT undergoing PTX vs matched population controls, before and after PTX
- PTXn = 5,009
- Controlsn = 14,983reference
- Outcome
- Incidence rate ratios (IRRs) before and after PTX for recurrent acute MI, stroke, TIA, and first-onset coronary artery disease, HF, aortic and mitral valve stenosis, carotid artery stenosis, peripheral artery disease and aortic aneurysm
Methodological detailsnation-wide, matched population controls, register-based
- Nation-wide
- Matched population controls
- Register-based
Main finding
As reported in the abstract
Transient ischemic attack (TIA) increased pre- and postoperatively, peak 1-4 years before PTX: IRR
2.06 (1.31-3.25) (95% CI)
Mitral valve stenosis increased preoperatively, not postoperatively: IRR
3.22 (1.51-6.85) (CI)
HF increased preoperatively, not postoperatively: IRR
1.37 (1.11-1.67) (CI)
Observational data: associations, not effects.
Original publication
Cardiovascular Morbidity in Patients Undergoing Successful Surgery for Primary Hyperparathyroidism. Clin Endocrinol (Oxf). Published 12 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →