Curative Parathyroidectomy in Primary Hyperparathyroidism Improves Both Systolic and Diastolic Cardiac Dysfunction: A Six‐Month Follow‐Up Study at a Tertiary Care Hospital
Authors' conclusion
This study demonstrates significant improvements in diastolic and systolic functions, as evidenced by conventional echocardiography and STE, and suggests that PTX benefits cardiovascular health in PHPT patients.
Study context
- Population
- Patients with primary hyperparathyroidism (PHPT) undergoing successful PTX at a tertiary care hospital, August 2016 to September 2019; mean age 45.2 ± 10.4 years, male-to-female ratio 1.5:158 completed
- Participants
- 59 patients
- Exposure
- Before vs 6 months after curative PTX
- Outcome
- Cardiac function after PTX (conventional echocardiography and STE)
- Follow-up
- 6 months postoperative
Methodological detailssingle-centre, pre-post (preoperative vs 6-month postoperative)
- Single-centre
- Pre-post (preoperative vs 6-month postoperative)
Main finding
As reported in the abstract
- Diastolic parameters (E velocity, E/A ratio) significantly improved
- Systolic dysfunction significantly improved on conventional echocardiography and speckle-tracking echocardiography (STE) (reduced left ventricular (LV) mass, ejection fraction (EF), postoperative global longitudinal strain (GLS))
- Relative drop in EF postprocedure, but STE suggested significant improvement in systolic dysfunction
Observational data: associations, not effects.
Further findings
Biochemistry after curative PTX
- Normalization of serum calcium and phosphorus; significant reductions in serum intact PTH, alkaline phosphate, total cholesterol, HDL and uric acid
- P ≤ 0.0001
Correlation of serum PTH with changes in GLS
- Strong positive correlation, r
- 0.638, p < 0.001
Correlation of serum calcium with changes in GLS
- Weak correlation, r
- 0.291, p = 0.027
Original publication
Curative Parathyroidectomy in Primary Hyperparathyroidism Improves Both Systolic and Diastolic Cardiac Dysfunction: A Six‐Month Follow‐Up Study at a Tertiary Care Hospital. Clin Endocrinol (Oxf). Published 28 January 2025. doi:10.
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