Effect of soluble corn fibre and calcium supplementation on bone mineral content and bone mineral density in preadolescent Malaysian children—a double-blind randomised controlled trial (PREBONE-Kids Study)
Authors' conclusion
SCF did not increase TBBMC and TBBMD in Malaysian children after 1 year although calcium supplementation increased TBBMD at 6 months. Further work is needed to fully understand the mechanism and health benefits of prebiotics in this study population.
Study context
- Population
- Healthy preadolescent Malaysian children aged 9–11 years
- Participants
- 243 children
- Comparison
- Soluble corn fibre (SCF), Ca and SCF + Ca vs placebo
- Primary endpoint
- TBBMC and TBBMD by dual-energy X-ray absorptiometry
- Follow-up
- Baseline, 6 and 12 months
Methodological detailsdouble-blind, parallel arm, four groups
- Double-blind
- Parallel arm
- Four groups
Primary result
As reported in the abstract
12 months
Increase in total body bone mineral content (TBBMC) from baseline, SCF + Ca
40.28 ± 9.03 g
p = 0.001
Increase in TBBMC from baseline, SCF
27.34 ± 7.93 g
p = 0.037
Further findings
| Outcome | Placebo | SCF | Ca | SCF + Ca | P value |
|---|---|---|---|---|---|
| Change in TBBMD · 6 monthsSCF + Ca and Ca vs SCF and Placebo · significantly different | 0.002 ± 0.003 g/cm² | 0.004 ± 0.002 g/cm² | 0.014 ± 0.003 g/cm² | 0.019 ± 0.003 g/cm² | P < 0.05 |
| Increase in TBBMC from baseline, SCF + Ca · 6 months | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract | 27.14 ± 6.10 g |
— not stated in the abstract
- Increase in TBBMC from baseline, SCF + Ca — Significant increase from baseline
- p = 0.001
Original publication
Effect of soluble corn fibre and calcium supplementation on bone mineral content and bone mineral density in preadolescent Malaysian children—a double-blind randomised controlled trial (PREBONE-Kids Study). Osteoporos Int. Published 21 February 2023. doi:10.
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