Influence of vitamin D supplementation on bone mineral content, bone turnover markers, and fracture risk in South African schoolchildren: multicenter double-blind randomized placebo-controlled trial (ViDiKids)
Authors' conclusion
In conclusion, a 3-yr course of weekly oral vitamin D supplementation elevated serum 25(OH)D3 concentrations and suppressed serum PTH concentrations in HIV-uninfected South African schoolchildren of Black African ancestry but did not influence BMC or serum concentrations of bone turnover markers.
Study context
- Population
- HIV-uninfected Cape Town schoolchildren aged 6–11 yr of Black African ancestry; baseline mean serum 25(OH)D3 70.0 nmol/L (SD 13.5), 5.8% <50 nmol/Lsub-study
- Participants
- 450 participants
- Comparison
- Weekly oral vitamin D3 10 000 IU vs placebo for 3 yr
- Primary endpoint
- BMC at whole body less head (WBLH) and LS
- Follow-up
- 3 yr
Methodological detailssub-study nested within phase 3 RCT, multicentre, double-blind, placebo-controlled
- Sub-study nested within phase 3 RCT
- Multicentre
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
BMC · end-trial
Estimate (95% CI)
Between Vitamin D and Placebo
aMD (WBLH BMC) −8.0 g(−30.7 to 14.7)
Between Vitamin D and Placebo
aMD (LS BMC) −0.3 g(−1.3 to 0.8)
Secondary outcomes
| Outcome | aMD (nmol/L) (95% CI) | |
|---|---|---|
| Serum 25(OH)D3 · end-trial | 39.9 (36.1–43.6) | |
| −200204060Difference, nmol/L (linear scale) |
| Outcome | aMD (pmol/L) (95% CI) | |
|---|---|---|
| Serum PTH · end-trial | −0.55 (−0.94 to −0.17) | |
| −1−0.500.5Difference, pmol/L (linear scale) |
| Outcome | Vitamin D | Placebo | aOR (95% CI) | |
|---|---|---|---|---|
| Fractures (main trial, attending ≥1 follow-up)Secondary outcome of main trial | 7/755 | 10/758 | 0.70 (0.27–1.85) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Bone turnover markers · end-trial
- No interarm differences in serum bone turnover markers
Original publication
Influence of vitamin D supplementation on bone mineral content, bone turnover markers, and fracture risk in South African schoolchildren: multicenter double-blind randomized placebo-controlled trial (ViDiKids). J Bone Miner Res. Published 10 January 2024. doi:10.
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