Ambient PM2.5 Components Are Associated With Bone Strength: Evidence From a China Multi-Ethnic Study
Authors' conclusion
We found that long-term exposure to PM2.5 and its components may lead to reduced bone strength, suggesting that PM2.5 and its components may potentially increase the risk of osteoporosis and even fracture. Nitrate may be responsible for increasing its risk to a greater extent.
Study context
- Population
- Individuals aged 30 to 79 years from the China Multi-Ethnic Cohort
- Participants
- 65,906 individuals
- Exposure
- Per-SD increase in 3-year average concentrations of PM2.5 and its components
- Outcome
- Bone strength: calcaneus quantitative ultrasound index (QUI)
Methodological detailslarge-scale epidemiologic survey, multi-ethnic, Exposure estimated using satellite remote sensing and chemical transport models; logistic regression and weighted quantile sum method
- Large-scale epidemiologic survey
- Multi-ethnic
- Exposure estimated using satellite remote sensing and chemical transport models; logistic regression and weighted quantile sum method
Main finding
As reported in the abstract
QUI per-SD increase (μg/m³) in 3-year average concentration
- PM2.5: MD
- −7.38 (−8.35 to −6.41) (95% CI)
- Black carbon: MD
- −7.91 (−8.90 to −6.92) (95% CI)
- Ammonium: MD
- −8.35 (−9.37 to −7.34) (95% CI)
- Nitrate: MD
- −8.73 (−9.80 to −7.66) (95% CI)
- Organic matter: MD
- −4.70 (−5.77 to −3.64) (95% CI)
- Soil particles: MD
- −5.12 (−6.10 to −4.15) (95% CI)
Observational data: associations, not effects.
Further findings
Subgroups
- Associations more pronounced in men, and people older than 65 years with a history of smoking and chronic alcohol consumption
Original publication
Ambient PM2.5 Components Are Associated With Bone Strength: Evidence From a China Multi-Ethnic Study. J Clin Endocrinol Metab. Published 19 July 2023. doi:10.
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