Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens
Authors' conclusion
This study supports a recommendation that different dosing regimens of vitamin D replacement will reach similar desirable levels when steady state is reached at weeks 12 and 36, thus enabling healthcare providers an option to determine the most appropriate replacement strategy based on individual patient preference and other variables.
Study context
- Population
- Community-dwelling vitamin D-deficient adults in Yerevan, Armenia; average age 44.8, 80% female; mean baseline 25(OH)D 19.4 ng/mL
- Participants
- 60 adults
- Comparison
- Three vitamin D repletion regimens: low dose-high frequency vs medium dose-medium frequency vs high dose-low frequency
- Primary endpoint
- Circulating 25(OH)D levels (efficacy of repletion)
- Follow-up
- Baseline and weeks 4, 8, 12, 24 and 36
Methodological detailsthree-arm
- Three-arm
Primary result
As reported in the abstract
Circulating 25(OH)D · baseline to week 36
All three arms: significant 25(OH)D increases from baseline to 4 weeks and from 4 to 8 weeks, then plateau
mid-40s ng/mL
Further findings
Mean, ng/mL
| Outcome | A | B | P value |
|---|---|---|---|
| 25(OH)D, A vs B · week 36 | 47.7 | 40.2 | p-value 0.007 |
| 25(OH)D, A vs B · mean baseline | 21.0 | 16.9 | p-value 0.03 |
Original publication
Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens. Osteoporos Int. Published 10 December 2025. doi:10.
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