Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study
An erratum to this article was published (Osteoporos Int, Dec 2024 ↗)
Authors' conclusion
Our study illustrates that exposure to nitrogen oxides and PM2.5 may lead to a decrease in total-body BMD, increasing the risk of osteoporosis.
Study context
- Population
- Publicly available genome-wide association studies (GWAS) data
- Comparison
- Genetically predicted air pollution exposure and total-body bone mineral density (BMD)
- Outcome
- Total-body BMD
Methodological detailsGWAS summary data, inverse variance weighting (primary), weighted median, MR-Egger, simple mode, weighted mode, sensitivity analyses for heterogeneity, pleiotropy and outliers
- GWAS summary data
- Inverse variance weighting (primary)
- Weighted median, MR-Egger, simple mode, weighted mode
- Sensitivity analyses for heterogeneity, pleiotropy and outliers
Main finding
As reported in the abstract
Total-body BMD (IVW Mendelian randomization (MR) estimate)
β
- 0.55
95% CI - 0.90 to - 0.21P = 0.002
Nitrogen oxides
β
- 0.33
95% CI - 0.59 to - 0.08P = 0.010
Particulate matter (PM) 2.5
Original publication
Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study. Osteoporos Int. Published 23 September 2024. doi:10.
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