Metabolically favorable adiposity and bone mineral density: a Mendelian randomization analysis
Authors' conclusion
This study did not support the hypothesis that MFA protects against low aBMD. Instead, it showed that MFA may result in lower aBMD. Further research is needed to understand how MFA affects aBMD and other components of bone health such as bone turnover, bone architecture, and osteoporotic fractures.
Study context
- Comparison
- Genetically predicted metabolically favorable adiposity (metabolically "favorable adiposity (MFA)) and percent body fat vs areal BMD
- Outcome
- Areal BMD at whole body, lumbar spine, femoral neck and forearm
Methodological detailssex-stratified and age-stratified exploratory analyses
- Sex-stratified and age-stratified exploratory analyses
Main finding
As reported in the abstract
MFA vs whole-body areal bone mineral density (aBMD), β (p = 0.0002)
−0.053
MFA vs lumbar spine aBMD, β (p = 0.0001)
−0.075
MFA vs femoral neck aBMD, β (p = 0.008)
−0.045
MFA vs forearm aBMD, β (p = 0.001)
−0.115
Further findings
Association of genetically predicted percent body fat with aBMD
- Nonsignificant across all MR analyses
MFA–aBMD association by age and sex
- Negative relationship strongest in older individuals; did not differ by sex
- Exploratory
Loci associated in opposite directions with body fat and aBMD
- Several loci identified at genome-wide significance (p < 5 × 10-8 )
Original publication
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