Exposure to Multiple Air Pollutants and the Risk of Fractures: A Large Prospective Population-Based Study
Main finding · Fracture risk by air pollution scoreResult — go to the resultHazard ratio 1.15 95% CI 1.09,1.22Study context
- Population
- UK Biobank participants free of fracture history at enrollment (2006 to 2010); environmental exposure data 2007 to 201012,288 incident fractures
- Participants
- 446,395 participants
- Exposure
- Highest vs lowest quintile of air pollution score
- Outcome
- Incident fractures
- Follow-up
- median 8-year follow-up
Methodological detailsUK Biobank, multivariable Cox proportional hazard models, mediation analyses
- UK Biobank
- Multivariable Cox proportional hazard models
- Mediation analyses
Main finding
Fracture risk by air pollution score
Hazard ratio
1.15
95% CI 1.09,1.22
Highest quintilevs Lowest quintile
HR 1.15 (95% CI 1.09,1.22)
As reported in the abstract
- Proportion of association mediated through serum 25(OH)D (pmediation < 0.05)
- 5.49%
Observational data: associations, not effects.
Further findings
Pollutant-specific fracture hazard, top vs bottom quintile
- PM2.5
- 16%
- PM2.5-10
- 4%
- PM10
- 5%
- NO2
- 20%
- NOx
- 17%
- Mediation effect of serum 25(OH)D
- 4% to 6%
Effect modification of air pollution score–fracture association
- Weaker association among female participants, those who drank less alcohol, and consumed more fresh fruit (pinteraction < 0.05)
Original publication
Exposure to Multiple Air Pollutants and the Risk of Fractures: A Large Prospective Population-Based Study. J Bone Miner Res. Published 17 July 2023. doi:10.
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