Pro‐Inflammatory Proteins Associated with Frailty and Its Progression—A Longitudinal Study in Community‐Dwelling Women
Authors' conclusion
The core proteins are compelling candidates for understanding the development and progression of frailty with advancing age, including the intrinsic musculoskeletal component.
Study context
- Population
- Community-dwelling women all aged 75 years at inclusion, Osteoporosis Prospective Risk Assessment (OPRA) cohort, reassessed at 80 and 85 yearsat age 75 · reassessed at 80 715 · 85 years 382
- Participants
- 1,044 participants
- Outcome
- Association of 92 plasma proteins (Olink CVD-II panel) with frailty index (FI), frailty status (frail FI ≥ 0.25) and their change
Methodological detailspopulation-based, nontargeted proteomics, cross-sectional and longitudinal analyses, false discovery rate (FDR)-controlled regression models, longitudinal mixed models
- Population-based
- Nontargeted proteomics
- Cross-sectional and longitudinal analyses
- FDR-controlled regression models
- Longitudinal mixed models
Main finding
As reported in the abstract
Proteins associated with frailty
- Proteins with elevated levels positively associated with frailty index (FI) cross-sectionally at all ages (β-coefficients 0.22-2.06; FDR 0.021-0.024)
- 32
- Of these, proteins also associated with frailty status (ORs 1.40-5.77; FDR 0.022-0.016)
- 18
- Proposed core proteins: CD4, FGF23, Gal-9, PAR-1, REN, TNFRSF10A, TNFRSF11A, TNFRSF10B
- 8
- One-unit change in FI additively associated with increased protein expression over 5 and 10 years (β-coefficients 0.52-1.59)
- p < 0.001
- Baseline FI increments associated with change in protein expression: 5 years β-range 0.05-1.35; 10 years β-range 0.51-1.48
- all p < 0.001
- One-unit increase in protein expression associated with increased probability of being frail (FI ≥ 0.25), β-range
- 0.14-0.61
Observational data: associations, not effects.
Original publication
Pro‐Inflammatory Proteins Associated with Frailty and Its Progression—A Longitudinal Study in Community‐Dwelling Women. J Bone Miner Res. Published 17 July 2023. doi:10.
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