Predicting fragility fractures based on frailty and bone mineral density among rural community-dwelling older adults
Authors' conclusion
Combining frailty with BMD provides a more accurate fracture risk assessment for individuals over 50 years.
Study context
- Population
- Rural community-dwelling older Koreans, Chungju Metabolic Disease Cohort study; 1955 (38.1%) males, 3171 (61.9%) females
- Participants
- 5,126 participants
- Exposure
- Frailty and bone mineral density (BMD) vs not, for fragility fracture risk
- Outcome
- Fragility fractures (any, vertebral, hip, other, MOF), assessed via structured medical interviews
Methodological detailsFrailty defined by Fried's frailty phenotype
- Frailty defined by Fried's frailty phenotype
Main finding
As reported in the abstract
- Osteoporosis, any fracture: aOR
- 1.89 (1.23-3.47) (95% CI)
- Osteoporosis, hip fracture: aOR
- 2.05 (1.37-2.98) (95% CI)
- Osteoporosis, other fracture: aOR
- 2.18 (1.06-4.50) (95% CI)
- Osteoporosis, major osteoporotic fracture (MOF): aOR
- 1.71 (1.03-3.63) (95% CI)
- Frail, any fracture: OR
- 2.12 (1.21-3.71) (95% CI)
- Frail, vertebral fracture: OR
- 2.48 (1.84-3.61) (95% CI)
- Frail, hip fracture: OR
- 2.52 (1.09-3.21) (95% CI)
- Frail, other fracture: OR
- 2.82 (1.19-8.53) (95% CI)
- Frail, MOF: OR
- 1.87 (1.01-3.47) (95% CI)
Observational data: associations, not effects.
Further findings
Subgroups by sex
- Frail women with osteoporosis, vertebral fracture: OR
- 5.12 (2.07-9.68) (95% CI)
- Frail women with osteoporosis, MOF: OR
- 5.19 (2.07-6.61) (95% CI)
- Men: significant association of frailty with osteoporosis in hip fracture and MOF
Age-specific analysis
- Age ≥70 had markedly higher fracture risks vs <70; frailty plus low BMD further elevated risk
Prediction of MOF: frailty with BMD vs either alone
- AUC, frailty + BMD
- 0.825; P = .000
Original publication
Predicting fragility fractures based on frailty and bone mineral density among rural community-dwelling older adults. Eur J Endocrinol. Published 6 July 2024. doi:10.
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