Frailty increases the long-term risk for fall and fracture-related hospitalizations and all-cause mortality in community-dwelling older women
Authors' conclusion
The FI identified community-dwelling older women at risk for the most serious falls and fractures
Study context
- Population
- Community-dwelling older women, mean age (SD) 75.1 (2.7) yr; Frailty index (FI) of cumulative deficits from 33 baseline variables (physical, mental, comorbidities)
- Participants
- 1,261 women
- Exposure
- Frailty index grades: mildly, moderately and severely frail vs fit
- Fitn = 713reference
- Mildly frailn = 350
- Moderately frailn = 163
- Severely frailn = 35
- Outcome
- Hospitalized falls, fractures (any and hip) and all-cause mortality, from linked health records
- Follow-up
- 14.5 yr
Methodological detailscommunity-dwelling, linked health records, multivariable-adjusted Cox proportional hazard models
- Community-dwelling
- Linked health records
- Multivariable-adjusted Cox proportional hazard models
Main finding
As reported in the abstract
Fall-related hospitalization
Higher hazard of fall-related hospitalization with mild, moderate and severe frailty, respectively (all P < .05)
46%, 104%, 168%
Observational data: associations, not effects.
Further findings
Any fracture-related hospitalization · 14.5 yr
- Higher hazard of any fracture-related hospitalization with moderate and severe frailty, respectively (P < .05)
- 88%, 193%
- Multivariable-adjusted Cox-proportional hazard models
Hip fracture-related hospitalization · 14.5 yr
- Higher hazard of hip fracture-related hospitalization with mild, moderate and severe frailty, respectively (all P < .05)
- 93%, 127%, 129%
- Multivariable-adjusted Cox-proportional hazard models
All-cause mortality · 14.5 yr
- Higher hazard of all-cause mortality with mild, moderate and severe frailty, respectively (all P < .05)
- 47%, 126%, 242%
- Multivariable-adjusted Cox-proportional hazard models
Original publication
Frailty increases the long-term risk for fall and fracture-related hospitalizations and all-cause mortality in community-dwelling older women. J Bone Miner Res. Published 4 January 2024. doi:10.
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