FRAX predicts cardiovascular risk in women undergoing osteoporosis screening: the Manitoba bone mineral density registry
Authors' conclusion
Although FRAX is intended for fracture risk prediction, it has predictive value for cardiovascular risk.
Study context
- Population
- Women aged ≥50 yr with a baseline DXA scan in the Manitoba Bone Mineral Density Registry, 1999–2018; mean age 65.7 ± 9.4 yr
- Participants
- 59,696 women
- Comparison
- FRAX major osteoporotic fracture (MOF) risk categories for prediction of MACE
- Outcome
- Incident MACE:
- Hospitalized acute MI
- Hospitalized non-hemorrhagic cerebrovascular disease
- All-cause death
- Follow-up
- Mean 8.7 yr of observation
Methodological detailsregistry-based
- Registry-based
Performance
As reported in the abstract
MACE rate per 1000 person-years by FRAX risk category · mean 8.7 yr
- HR for MACE per SD increase in FRAX
- 1.99 (95%CI, 1.96-2.02)
Further findings
Incident events overall · mean 8.7 yr
- MOF
- 6021 (10.1%)
- MACE
- 12 277 (20.6%)
- AMI
- 2274 (3.8%)
- CVA
- 2061 (3.5%)
- Died
- 10 253 (17.2%)
FRAX-defined risk factors and non-death CV events
- All FRAX-defined risk factors (except parental hip fracture and lower BMI) independently associated with higher non-death CV events
Original publication
FRAX predicts cardiovascular risk in women undergoing osteoporosis screening: the Manitoba bone mineral density registry. J Bone Miner Res. Published 4 January 2024. doi:10.
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