Incidence and Prevalence of Fibrous Dysplasia/McCune-Albright Syndrome: A Nationwide Registry-Based Study in Denmark
Authors' conclusion
FD/MAS is rare, diagnosis peaks during adolescence without sex predominance, and MFD is most prevalent. Hypophosphatemia may be underdiagnosed and undertreated, or it may be underregistered, comparing this study to literature.
Study context
- Population
- Patients with FD/MAS in the Danish National Patient Registry, 1995–2018
- Participants
- 408 patients
- Exposure
- MFD vs PFD/MAS
- MFDn = 269
- PFD/MASn = 139
- Outcome
- Incidence and prevalence of FD/MAS and FD/MAS-related hypophosphatemia
Main finding
As reported in the abstract
Incidence and prevalence of FD/MAS
- Patients identified
- 408
- MFD
- 269 (66%)
- PFD/MAS
- 139 (34%)
- Incidence of FD/MAS in 2015-2018 (increasing secular trend)
- 3.6 per 1 000 000 person-years (95% CI: 2.9, 4.5)
- Prevalence of FD/MAS in 2018 (increased over time)
- 61.0 (95% CI: 54.6, 67.4) per 1 000 000 persons
- Incidence rate of MFD vs PFD/MAS, first decade
- 1.5-fold
- Incidence rate of MFD vs PFD/MAS, last decade
- 2.5-fold
Observational data: associations, not effects.
Original publication
Incidence and Prevalence of Fibrous Dysplasia/McCune-Albright Syndrome: A Nationwide Registry-Based Study in Denmark. J Clin Endocrinol Metab. Published 4 January 2024. doi:10.
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