Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures
Authors' conclusion
These analyses identified several circulating proteins and pathways consistently associated with incident hip fractures.
Study context
- Population
- Subjects from two prospective cohort studies (Cardiovascular Health Study and Trøndelag Health Study) with circulating proteomics data
- Participants
- 6,430 subjects2 cohorts
- Outcome
- Incident hip fractures
Methodological detailsinverse-variance weighted meta-analysis, age and sex-adjusted Cox regression, exploratory, aptamer-based 5 K SomaScan version 4.0 assay; 4979 aptamers
- Inverse-variance weighted meta-analysis
- Age and sex-adjusted Cox regression
- Exploratory
- Aptamer-based 5 K SomaScan version 4.0 assay; 4979 aptamers
Pooled result
As reported in the abstract
Circulating proteins associated with incident hip fractures
Incident hip fractures
643
Aptamers associated with incident hip fractures (Bonferroni 0.05/4979, P < 1.0 × 10-5)
23
Further pooled results
Ingenuity pathway analysis
- Reduced LXR/RXR activation and increased acute phase response signaling overrepresented among proteins associated with increased hip fracture risk
Original publication
Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures. J Bone Miner Res. Published 4 January 2024. doi:10.
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