Low Circulating Valine Associate With High Risk of Hip Fractures
Authors' conclusion
Low circulating valine is a robust predictor of incident hip fractures. We propose that circulating valine may add information for hip fracture prediction. Future studies are warranted to determine whether low valine is causally associated with hip fractures.
Study context
- Population
- UK Biobank participants (discovery); Umeå Fracture and Osteoporosis (UFO) hip fracture cases and controls (replication); MrOS Sweden subsample for bone microstructureUK Biobank
- Participants
- 111,257 participants
- Comparison
- Circulating valine per SD increase
- Outcome
- Incident hip fracture
Methodological detailsdiscovery cohort (UK Biobank), replication in UFO hip fracture study, meta-analysis of discovery and replication
- Discovery cohort (UK Biobank)
- Replication in UFO hip fracture study
- Meta-analysis of discovery and replication
Main finding
As reported in the abstract
Hip fracture per SD increase in circulating valine
HR per SD increase, UK Biobank
0.79
95% CI 0.73–0.84
OR per SD increase, combined meta-analysis, 3126 incident hip fracture cases
0.84
95% CI 0.80–0.88
Observational data: associations, not effects.
Further findings
Bone microstructure (MrOS Sweden subsample, n = 449)
- High circulating valine associated with high cortical bone area and trabecular thickness
Original publication
Low Circulating Valine Associate With High Risk of Hip Fractures. J Clin Endocrinol Metab. Published 13 May 2023. doi:10.
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