Lesion expansion in craniofacial fibrous dysplasia: natural history and indicators of progression in the frontal, zygomatic, and sphenoid bones
Authors' conclusion
Craniofacial lesion expansion rates are most rapid in younger children (generally below age 10) and decline as patients approach adulthood. FD lesions involving the frontal bone expand at a greater rate than sphenoid, zygomatic, and previously- reported gnathic lesions.
Study context
- Population
- Patients with craniofacial fibrous dysplasia (FD) (fibrous dysplasia), including McCune-Albright syndrome, with serial CT imaging; lesions of frontal, zygomatic, sphenoid bones plus previous gnathic (mandible, maxilla) dataset
- Participants
- 70 patients238 lesions
- Outcome
- Expansion rates of periorbital (frontal, zygomatic, sphenoid) FD lesions
Methodological detailsserial CT imaging, volumetric analyses, generalized mixed model analysis
- Serial CT imaging
- Volumetric analyses
- Generalized mixed model analysis
Main finding
As reported in the abstract
- Frontal, zygomatic, and sphenoid lesion volume increased with age
- p<0.001
- Expansion rates decreased over time
- p<0.001
Observational data: associations, not effects.
Further findings
Risk factors for lesion expansion
- GH excess associated with greater lesion expansion rates
- P = 0.0173
- No associations with sex, other McCune-Albright syndrome (MAS)-associated endocrinopathies, or bisphosphonate treatment
Original publication
Lesion expansion in craniofacial fibrous dysplasia: natural history and indicators of progression in the frontal, zygomatic, and sphenoid bones. J Bone Miner Res. Published 25 August 2026. doi:10.
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