Associations of Gestational Exposure to Air Pollution With Maternal Vitamin D Levels: A Meta-Analysis
Authors' conclusion
PM2.5 exposure might contribute to suboptimal levels of vitamin D in pregnancy. Reducing air pollution exposure should be a priority because vitamin D deficiency may adversely influence offspring development.
Study context
- Population
- Pregnant women from 5 birth cohorts in Europe and the United States; 25(OH)D or 25(OH)D3 measured in serum or plasma at early or mid-pregnancy
- Participants
- 15,935 women5 birth cohorts
- Comparison
- Gestational air pollution exposure and suboptimal maternal vitamin D levels
- Outcome
- Suboptimal vitamin D levels (<20 ng/mL)
- Follow-up
- Early or mid-pregnancy
Methodological detailsrandom-effect meta-analysis, logistic regression per cohort, adjusted for sociodemographic and lifestyle characteristics and month of conception, Exposures (nitrogen oxides, fine and coarse particles, fine particle composition) from conception until vitamin D measurement estimated at residential addresses using land-use regression or other spatiotemporal models
- Random-effect meta-analysis
- Logistic regression per cohort
- Adjusted for sociodemographic and lifestyle characteristics and month of conception
- Exposures (nitrogen oxides, fine and coarse particles, fine particle composition) from conception until vitamin D measurement estimated at residential addresses using land-use regression or other spatiotemporal models
Pooled result
As reported in the abstract
OR per 5 μg/m³ increase in PM2.5
1.43
95% CI 1.02, 1.99
Original publication
Associations of Gestational Exposure to Air Pollution With Maternal Vitamin D Levels: A Meta-Analysis. J Clin Endocrinol Metab. Published 13 June 2024. doi:10.
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