Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss
Study context
- Population
- Healthy males and females aged 55–70 years with DXA T-scores > −2.5 without vitamin D deficiency
- Participants
- 311 males
- Comparison
- Vitamin D3 400 IU vs 4000 IU vs 10,000 IU daily
- 400 IUn = 109reference
- 4000 IUn = 100
- 10,000 IUn = 102
- Primary endpoint
- Effect of vitamin D dose on plasma vitamin D metabolome (LC-MS/MS) and association of peak metabolite values with change in radial and tibial TtBMD (HR-pQCT), linear regression controlling for sex
- Follow-up
- 36 months
Methodological details36-month, HR-pQCT radius and tibia scans and blood sampling at baseline, 6, 12, 24, and 36 months
- 36-month
- HR-pQCT radius and tibia scans and blood sampling at baseline, 6, 12, 24, and 36 months
Primary result
As reported in the abstract
- Radius tibial total bone mineral density (TtBMD): slope for 25-(OH)D3 , female (significant sex interaction)
- −0.01, 95% CI −0.12, −0.07
- Radius TtBMD: slope for 25-(OH)D3 , male (significant sex interaction)
- −0.04, 95% CI −0.06, −0.01, p = 0.001
- Radius TtBMD: slope for 24,25-(OH)2 D3 , female (significant sex interaction)
- −0.75, 95% CI −0.98, −0.52
- Radius TtBMD: slope for 24,25-(OH)2 D3 , male (significant sex interaction)
- −0.35, 95% CI −0.59, −0.11, p < 0.001
- Tibia TtBMD: slope for 25-(OH)D3 , controlling for sex
- −0.03, 95% CI −0.05, −0.01, p < 0.001
- Tibia TtBMD: slope for 24,25-(OH)2 D3 , controlling for sex
- −0.30, 95% CI −0.44, −0.16, p < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss. J Bone Miner Res. Published 17 July 2023. doi:10.
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