The association between physical activity during growth and bone microarchitecture at peak bone mass
Authors' conclusion
Physical activity during growth is associated with greater BMD and failure load at PBM, 2 predictors of lifelong fracture risk. However, compartment-specific differences indicate that trabecular bone, as opposed to cortical bone, is more responsive to physical activity during growth.
Study context
- Population
- Individuals aged 18–35 years surrounding peak bone mass (PBM); HR-pQCT at distal radius and tibia, DXA at lumbar spine and femoral neck; physical activity during growth by bone-specific physical activity questionnaire (BPAQ)
- Participants
- 226 individuals
- Exposure
- Females vs Males
- Femalesn = 142
- Malesn = 84
- Outcome
- Association of physical activity during growth (gBPAQ) with bone properties at PBM
Main finding
As reported in the abstract
- Higher gBPAQ associated with higher tibia failure load and femoral neck areal BMD, both sexes
- ρ = 0.27-0.38, p ≤ .02
- Higher gBPAQ associated with better tibia trabecular BMD and bone volume fraction, males
- ρ = 0.40-0.41, p < .01
- Higher gBPAQ associated with better tibia trabecular BMD and bone volume fraction, females
- ρ = 0.24-0.26, p < .05
- Males: trabecular number, separation and inhomogeneity at radius
- ρ = 0.30-0.34, p ≤ .01
- Males: trabecular number, separation and inhomogeneity at tibia
- ρ = 0.31-0.42, p ≤ .02
Observational data: associations, not effects.
Original publication
The association between physical activity during growth and bone microarchitecture at peak bone mass. J Bone Miner Res. Published 29 July 2025. doi:10.
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