Revisiting the Osteoporosis Self-Assessment Tool (OST): evidence from a multi-cohort study in Asia supporting age-dependent thresholds
Authors' conclusion
OST thresholds show substantial variation in performance across age groups.
Study context
- Population
- Women ≥ 50 years and men ≥ 60 years from three cohorts in Asia; osteoporosis = DXA T-score ≤ −2.5 at lumbar spine, total hip or femoral neckthree cohorts · Women ≥ 50 years 2,787 · men ≥ 60 years 1,465
- Comparison
- OST thresholds: original (≤ −1), historical (≤ −4), Youden index-derived and screening-oriented (80% sensitivity), vs DXA-defined osteoporosis
- Outcome
- OST discrimination and threshold performance for DXA-defined osteoporosis
Methodological detailsmulti-cohort, multi-ethnic, fivefold cross-validation
- Multi-cohort
- Multi-ethnic
- Fivefold cross-validation
Performance
As reported in the abstract
- AUC, women
- 0.79
- AUC, men
- 0.72
- - 1 threshold: sensitivity, women aged 50-59 years
- 0.54
- - 1 threshold: specificity, women aged 70-79 years
- 0.21
- - 1 threshold: specificity, women aged ≥ 80 years
- 0.03
- - 4 threshold: sensitivity, women aged 50-59 years
- 0.02
- - 4 threshold: sensitivity, women aged 60-69 years
- 0.14
- Youden thresholds, 50-59 years to ≥ 80 years
- - 0.15 to - 6.20
- Youden thresholds on cross-validation, mean (SD)
- - 2.18 (0.45)
- Screening thresholds targeting 80% sensitivity, age-dependent range
- + 0.25 to - 5.39
Original publication
Revisiting the Osteoporosis Self-Assessment Tool (OST): evidence from a multi-cohort study in Asia supporting age-dependent thresholds. Osteoporos Int. Published 26 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →