Testosterone, sex hormone-binding globulin, and fracture risk in men: evidence from observational and Mendelian randomization analyses
Authors' conclusion
Our findings suggest that the interplay between TT and SHBG is important in determining fracture risk
Study context
- Population
- Men from the UK Biobank with baseline serum total testosterone (TT) and sex hormone-binding globulin (SHBG) measurements and genetic data (median age 59.0 years)7,493 with fractures
- Participants
- 162,786 men
- Exposure
- Higher TT and lower SHBG vs lower TT and higher SHBG
- Outcome
- Incident fracture
Methodological detailsCox proportional hazards models, 2 × 2 factorial Mendelian randomization, 13.3 years follow-up
- Cox proportional hazards models
- 2 × 2 factorial Mendelian randomization
- 13.3 years follow-up
Main finding
As reported in the abstract
Total fracture
Estimate (95% CI)
Highest quintile of Bio-Tvs Lowest quintile of Bio-T
aHR 0.72(0.67–0.78)
Genetically higher TT and lower SHBGvs Genetically lower TT and higher SHBGfactorial MR analysis
OR 0.87(0.80–0.95)
Observational data: associations, not effects.
Original publication
Testosterone, sex hormone-binding globulin, and fracture risk in men: evidence from observational and Mendelian randomization analyses. Osteoporos Int. Published 15 July 2025. doi:10.
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