Comparative effectiveness of denosumab vs alendronate among postmenopausal women with osteoporosis
Authors' conclusion
In this cohort of almost half-a-million treatment-naive women with PMO, we observed clinically significant reductions in the risk of MOP, hip, NV, NHNV, and HV fractures for patients on denosumab compared with alendronate. Patients who remained on denosumab for longer periods of time experienced greater reductions in fracture risk.
Study context
- Population
- Treatment-naive women with postmenopausal osteoporosis aged ≥66 yr, Medicare fee-for-service beneficiaries, US, initiating treatment 2012–2018; followed to December 31, 2019treatment-naive
- Participants
- 89,115 vs 389,536
- Exposure
- Denosumab vs alendronate
- Denosumabn = 89,115
- Alendronaten = 389,536reference
- Outcome
- Risk of hip, nonvertebral, non-hip nonvertebral, hospitalized vertebral and major osteoporotic fractures
Methodological detailsadministrative claims data, doubly robust inverse-probability of treatment and censoring weighting
- Administrative claims data
- Doubly robust inverse-probability of treatment and censoring weighting
Main finding
As reported in the abstract
Fracture risk reduction with denosumab vs alendronate (overall)
- Major osteoporotic fracture risk reduction
- 39%
- Hip fracture risk reduction
- 36%
- Nonvertebral fracture risk reduction
- 43%
- Non-hip nonvertebral fracture risk reduction
- 50%
- Hospitalized vertebral fracture risk reduction
- 30%
Observational data: associations, not effects.
Further findings
Major osteoporotic fracture risk reduction by duration of exposure
- Year 1
- 9%
- Year 2
- 12%
- Year 3
- 18%
- Year 5
- 31%
- Increasing risk reduction with increasing duration of exposure also observed for other nonvertebral (NV) fracture outcomes
Original publication
Comparative effectiveness of denosumab vs alendronate among postmenopausal women with osteoporosis. J Bone Miner Res. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →