Genetic predisposition to bone mineral density and their health conditions in East Asians
Authors' conclusion
This study identified key genetic factors for bone health in Taiwan, and revealed significant health conditions in EAS, particularly highlighting the genetic interplay between bone health and metabolic traits like T2D and BMI.
Study context
- Population
- Individuals from the Taiwan Biobank, East AsiansTaiwan Biobank
- Participants
- 86,716 individuals
- Outcome
- Genetic loci for BMD
Methodological detailsgene-based genome-wide association study (GWAS), polygenic risk score assessments, cross-trait linkage disequilibrium score regression, bidirectional Mendelian randomization
- Gene-based GWAS
- Polygenic risk score assessments
- Cross-trait linkage disequilibrium score regression
- Bidirectional Mendelian randomization
Performance
As reported in the abstract
Significant SNPs related to BMD
78
Genes related to BMD
75
Further findings
Genetic correlations (cross-trait LD score regression)
- BMD and osteoporosis consistently genetically correlated with BMI and T2D in East Asians (EAS)
Observational associations
- Higher BMD linked to lower osteoporosis risk but increased BMI and T2D
- Osteoporosis linked to lower BMI, waist circumference, HbA1c and reduced T2D risk
Bidirectional Mendelian randomization
- Higher BMI causally increases BMD in EAS
- No direct causal relationship between BMD and T2D, or between osteoporosis and BMI or T2D
Original publication
Genetic predisposition to bone mineral density and their health conditions in East Asians. J Bone Miner Res. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →