Increased prevalence of coronary artery calcification in patients with post-surgical hypoparathyroidism
Main finding · Coronary atherosclerotic plaquesResult — go to the resultAdjusted difference in prevalence 24 percentage pointsAuthors' conclusion
In conclusion, chronic post-surgical hypoparathyroidism is associated with an increased burden of atherosclerosis, which may explain the increased cardiovascular risk.
Study context
- Population
- Patients with chronic post-surgical hypoparathyroidism (mean age 60 [range 31–84] years, 86% female, median duration 12 [range 5–49] years) and matched general-population controlsage- and sex-matched
- Participants
- 50 vs 50
- Exposure
- Chronic post-surgical hypoparathyroidism vs general-population controls
- Hypoparathyroidismn = 50
- Controlsn = 50reference
- Outcome
- Coronary artery disease on coronary CT angiography
Methodological detailsage- and sex-matched controls, coronary CT angiography
- Age- and sex-matched controls
- Coronary CT angiography
Main finding
Coronary atherosclerotic plaques
Adjusted difference in prevalence
24 percentage points
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
eGFR · lower with Hypoparathyroidism
P = 0.04
Antihypertensive medication · more frequent with Hypoparathyroidism
P = 0.05
Severe coronary artery disease (coronary artery calcium score ≥400)
P = 0.02
Aortic valve calcification · more often with Hypoparathyroidism
P < 0.01
- Lipid-lowering therapy
- P = 0.07
- Calcifications of the ascending and descending aorta
- P < 0.01
Lipid-lowering therapy
- Use of lipid-lowering therapy was more frequent
Diabetes, smoking status and arterial stiffness (carotid-femoral wave velocity)
- Did not differ between groups
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →