Hypoparathyroidism: changes in brain structure, cognitive impairment, and reduced quality of life
Authors' conclusion
HypoPT is associated with quantifiable cognitive deficits and changes in brain structure that align with patient symptoms.
Study context
- Population
- Well-treated post-surgical and non-surgical hypoparathyroid patients and healthy controls
- Exposure
- Post-surgical and non-surgical hypoparathyroidism (HypoPT) vs healthy controls
- Outcome
- QOL, cognitive function and brain structure
Methodological detailsexploratory, quality of life (QOL) by SF36v2, WHO-5 wellbeing Index, HPQ28 and Hypoparathyroidism Symptom Diary; comprehensive neuropsychological testing; brain structure by MRI morphological analyses
- Exploratory
- QOL by SF36v2, WHO-5 wellbeing Index, HPQ28 and Hypoparathyroidism Symptom Diary; comprehensive neuropsychological testing; brain structure by MRI morphological analyses
Main finding
As reported in the abstract
- Reduced QOL in HypoPT
- Reduced cognitive functioning (processing speed, executive functions, visual memory, auditory memory) in HypoPT
- Reduced hippocampal volume in HypoPT
- Thalamus size associated with disease duration in postsurgical patients
- Smaller hippocampus in patients reporting severe brain fog vs less brain fog
Observational data: associations, not effects.
Original publication
Hypoparathyroidism: changes in brain structure, cognitive impairment, and reduced quality of life. J Bone Miner Res. Published 22 April 2024. doi:10.
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